Molecular and Therapeutic Interactions in Colorectal Cancer

Grant number: 1080491 | Funding period: 2015 - 2017

Completed

Abstract

This project will use our unique preclinical models to unravel the molecular and cellular events underlying the cooperation between two important cancer-causing pathways, PI3K and Apc/Wnt, in driving the development of cancer in the gastrointestinal tract. Our studies will provide critical new insights into the clinical significance of this interaction as well as the potential role of these pathways in the prophylactic and therapeutic actions of aspirin in the context of colorectal cancer.

Related publications (5)

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PI3K Activation in Neural Stem Cells Drives Tumorigenesis which can be Ameliorated by Targeting the cAMP Response Element Binding (CREB) Protein

Paul M Daniel, Gulay Filiz, Daniel V Brown, Michael Christie, Paul M Waring, Yi Zhang, John M Haynes, Colin Pouton, Dustin Flanagan, Elizabeth Vincan, Terrance G Johns, Karen Montgomery, Wayne A Phillips, Theo Mantamadiotis

2018-10-01

BACKGROUND: Hyperactivation of phosphoinositide 3-kinase (PI3K) signaling is common in cancers, but the precise role of the pathwa..

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Identifi cation of pik3ca mutation as a genetic driver of prostate cancer that cooperates with pten loss to accelerate progression and castration-resistant growth

HB Pearson, J Li, VS Meniel, CM Fennell, P Waring, KG Montgomery, RJ Rebello, AA Macpherson, S Koushyar, L Furic, C Cullinane, RW Clarkson, MJ Smalley, KJ Simpson, TJ Phesse, PR Shepherd, PO Humbert, OJ Sansom, WA Phillips

2018-06-01

Genetic alterations that potentiate PI3K signaling are frequent in prostate cancer, yet how different genetic drivers of the PI3K ..

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Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling

IM Berenjeno, R Piñeiro, SD Castillo, W Pearce, N McGranahan, SM Dewhurst, V Meniel, NJ Birkbak, E Lau, L Sansregret, D Morelli, N Kanu, S Srinivas, M Graupera, VER Parker, KG Montgomery, LS Moniz, CL Scudamore, WA Phillips, RK Semple

2017-12-01

Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of m..

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Combined MEK and Pi3'-kinase inhibition reveals synergy in targeting thyroid cancer in vitro and in vivo

O ElMokh, D Ruffieux-Daidié, MA Roelli, A Stooss, WA Phillips, J Gertsch, MS Dettmer, RP Charles

2017-01-01

Anaplastic thyroid cancers and radioiodine resistant thyroid cancer are posing a major treat since surgery combined with Iodine<su..

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PIK3CAH1047R-induced paradoxical ERK activation results in resistance to BRAFV600E specific inhibitors in BRAFV600E PIK3CAH1047R double mutant thyroid tumors

MA Roelli, D Ruffieux-Daidié, A Stooss, O ElMokh, WA Phillips, MS Dettmer, RP Charles

2017-01-01

Thyroid carcinomas are the most prevalent endocrine cancers. The BRAF<sup>V600E</sup> mutation is found in 40% of the papillary ty..

University of Melbourne Researchers